Clinical Microbiology Procedures Handbook

Section 11: Immunology

11.29 Serologic Tests for Diagnosis of Histoplasma Capsulatum

Last Updated:2022
11.29.1 Introduction

Histoplasmosis is the most common endemic fungal infection in the United States, where it is endemic in the Ohio and Mississippi river valleys. Infection with Histoplasma capsulatum is generally due to environmental exposure and is not considered ...

11.29.2 Histoplasma capsulatum Antibody Detection by Complement Fixation

The complement fixation (CF) test is a semiquantitative test that measures antibodies against heat‐killed Histoplasma capsulatum yeast‐phase cells and mycelium phase (histoplasmin). Antibodies against the yeast phase antigens appear first in acute ...

11.29.3 Histoplasma capsulatum Antibody Detection by Immunodiffusion (ID)

The immunodiffusion test is generally a qualitative test based on the principles of double diffusion, first described by Ouchterlony and Oudin…


Author: Patricia Slev
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