Clinical Microbiology Procedures Handbook

Section 13: Serology

13.4 Detection of Francisella tularensis Antibodies

Last Updated:2023
13.4.1 Introduction

Tularemia is a disease with multiple clinical forms (i.e., ulceroglandular, glandular, oculoglandular, and pneumonic), which results from infection by Francisella tularensis, a facultative…

13.4.2 Detection of Francisella tularensis Antibodies by Agglutination

Serial dilutions of serum are incubated with a fixed amount of antigen. The multivalent nature of antibodies allows binding of a single antibody molecule to multiple antigens and subsequent…

13.4.3 Detection of Francisella tularensis Antibodies by ELISA

No ELISA for F. tularensis is FDA approved for use in the United States; however, the IgM and IgG Serion ELISAs have been used in other countries. In the United States, derivatives of these assays are commercially available…


Section Editor: Elitza S. Theel

Editors in Chief: Amy L. Leber and Carey-Ann D. Burnham

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